In Old School RuneScape (OSRS), bossing is one of the best ways to earn OSRS gold, and players often flock to different bosses to maximize their profit. The profitability of a boss depends on various factors, such as drop rates, kill times, and personal efficiency. Here are the ten most profitable bosses that OSRS has to offer.

1.Theatre of Blood (Raids 2)

The Theatre of Blood is considered one of the most challenging and rewarding group activities in OSRS. It's known for its end-game gear drops such as the Scythe of Vitur, which can fetch upwards of 1 billion gold, and the Avernic Defender Hilt, which regularly sells for over 60 million gold. Players can expect an average of 5-7 million GP per hour, depending on skill and team efficiency.

Recommended Setup: High-level melee gear, full Bandos, Scythe of Vitur, or Rapier.

Requirements: 90+ Combat stats, high Slayer level, and teamwork.

Notable Drops: Scythe of Vitur, Justiciar Armour pieces, Ghrazi Rapier.

2. Chambers of Xeric (Raids 1)

Chambers of Xeric is another lucrative end-game boss for high-level players. Items like the Twisted Bow and Kodai Wand can make a single raid worth hundreds of millions of gold. With efficient raiding teams, players can earn 4-6 million GP per hour.

Recommended Setup: High-level ranged and magic gear, full Ancestral, Twisted Bow, or Dragon Hunter Crossbow.

Requirements: 90+ Combat stats, high Agility, Herblore, and Construction.

Notable Drops: Twisted Bow, Kodai Wand, Dragon Hunter Crossbow.

3. Nex

Nex is a formidable foe located in the God Wars Dungeon and is one of the newest bosses added to OSRS. She drops items like the Torva armour set and the Zaryte Crossbow, which can be sold for hundreds of millions of gold. Players can average 5-8 million GP per hour depending on luck and kill efficiency.

Recommended Setup: High-level ranged and melee gear, full Armadyl or Torva, Zaryte Crossbow, or Scythe of Vitur.

Requirements: 90+ Combat stats, Frozen Key, high Prayer and Magic levels.

Notable Drops: Torva Armour pieces, Nihil Shards, Zaryte Crossbow.

4. The Nightmare of Ashihama & Phosani’s Nightmare

The Nightmare of Ashihama and its harder variant, Phosani’s Nightmare, drop items like the Inquisitor’s Armour set and the Nightmare Staff, along with valuable orbs like the Harmonised Orb, Eldritch Orb, and Volatile Orb. Depending on solo or group performance, players can expect 4-6 million GP per hour.

Recommended Setup: High-level melee and magic gear, Dragon Warhammer, Inquisitor's Armour.

Requirements: 90+ Combat stats, Prayer flicking ability, high-level Herblore.

Notable Drops: Inquisitor’s Armour pieces, Nightmare Staff, Orbs.

5. Alchemical Hydra

The Alchemical Hydra is a popular Slayer boss located in the Karuulm Slayer Dungeon. The Hydra drops some of the best items in the game, like the Hydra’s Claw, which is used to create the Dragon Hunter Lance, and the Hydra Leather. With max efficiency, players can expect 4-5 million GP per hour.

Recommended Setup: Ranged setup with Twisted Bow or Dragon Hunter Crossbow.

Requirements: 95 Slayer, Anti-fire potions, good knowledge of mechanics.

Notable Drops: Hydra’s Claw, Hydra Leather, Alchemical Hydra Heads.

6. Corrupted Gauntlet

The Corrupted Gauntlet is a solo boss found in Prifddinas, offering high profits due to its unique drops like the Blade of Saeldor and Crystal Armour seeds. The Corrupted Gauntlet can yield up to 3-4 million GP per hour, depending on completion times and drop rates.

Recommended Setup: Crystal Armour, any powerful ranged or melee weapon.

Requirements: Song of the Elves quest completion, 90+ Combat stats, and high Agility and Construction.

Notable Drops: Blade of Saeldor, Crystal Armour seeds, Enhanced Crystal Weapon Seed.

7. Vorkath

Vorkath is a boss you fight after the completion of Dragon Slayer II and is known for its consistent profit, dropping items like the Dragonbone Necklace and Vorkath’s Head. Players can achieve 3-5 million GP per hour depending on gear and kill times.

Recommended Setup: Ranged setup with Dragon Hunter Crossbow, Armadyl Crossbow.

Requirements: Dragon Slayer II completion, high Combat stats.

Notable Drops: Dragonbone Necklace, Vorkath’s Head, Dragon Bolts.

8. Zulrah

Zulrah is a snake-like boss that drops highly sought-after items like the Toxic Blowpipe, Serpentine Helm, and Magic Fang. With its accessible requirements and consistent drops, players can earn 2-4 million GP per hour.

Recommended Setup: Hybrid setup with Trident of the Seas, Blowpipe, and Serpentine Helm.

Requirements: Regicide completion, high-level Ranged and Magic.

Notable Drops: Tanzanite Fang, Magic Fang, Uncut Onyx.

9. Cerberus

Cerberus is a Slayer boss that drops valuable crystals like the Primordial, Pegasian, and Eternal crystals, making it a profitable option for high-level Slayer enthusiasts. Players can expect 3-4 million GP per hour.

Recommended Setup: High-level melee gear with Dragon Warhammer.

Requirements: 91 Slayer, Anti-fire potions, and good knowledge of mechanics.

Notable Drops: Primordial Crystal, Eternal Crystal, Smouldering Stone.

10. Callisto, Venenatis, and Vet’ion (Wilderness Bosses)

The Wilderness bosses—Callisto, Venenatis, and Vet’ion—are notorious for their high-risk, high-reward nature. Their unique drops, like the Dragon Pickaxe and various rings, can bring in 2-4 million GP per hour. However, players must be wary of player-killers (PKers) while bossing in the Wilderness.

Recommended Setup: High-level ranged or melee gear with quick teleport options.

Requirements: 90+ Combat stats, wilderness navigation skills.

Notable Drops: Dragon Pickaxe, Ring of the Gods, Dragon 2h Sword.

Final Thoughts

Bossing in OSRS is not just about OSRS gold per hour, but also about the enjoyment and challenge each encounter offers. Whether you’re raiding with friends in the Theatre of Blood or testing your mettle against the Corrupted Gauntlet, these ten bosses provide some of the best opportunities for profit and excitement. Consider your own skills, gear, and preferences when deciding which boss to tackle next. Happy bossing!